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  <xs:element name="MilestonePaymentsObligationToBePaidThereafter" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_MilestonePaymentsObligationToBePaidThereafter"/>
  <xs:element name="SalesMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_SalesMilestonePayments"/>
  <xs:element name="ApproximatelyAgreement" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_ApproximatelyAgreement"/>
  <xs:element name="LicenseMaintenanceFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_LicenseMaintenanceFee"/>
  <xs:element name="MilestonePaymentsObligationToBePaidFirstThroughThirdYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_MilestonePaymentsObligationToBePaidFirstThroughThirdYear"/>
  <xs:element name="MilestonePaymentsObligationToBePaidFourthThroughSixthYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_MilestonePaymentsObligationToBePaidFourthThroughSixthYear"/>
  <xs:element name="ClinicalDevelopmentMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_ClinicalDevelopmentMilestonePayments"/>
  <xs:element name="WarrantsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="jspr_WarrantsDetailsTable"/>
  <xs:element name="PreFundedWarrantPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PreFundedWarrantPercentage"/>
  <xs:element name="PercentageOfElectionHolderWarrants" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PercentageOfElectionHolderWarrants"/>
  <xs:element name="PercentagePreFundedWarrants" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PercentagePreFundedWarrants"/>
  <xs:element name="PercentageOfCommonWarrants" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PercentageOfCommonWarrants"/>
  <xs:element name="CommitmentsandContingenciesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="jspr_CommitmentsandContingenciesDetailsTable"/>
  <xs:element name="ResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_ResearchAndDevelopmentExpenses"/>
  <xs:element name="CommonStockDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="jspr_CommonStockDetailsTable"/>
  <xs:element name="NumberOfSharePurchase" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="jspr_NumberOfSharePurchase"/>
  <xs:element name="VotingCommonStockPercent" type="dtr:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="jspr_VotingCommonStockPercent"/>
  <xs:element name="PurchaseAnAggregateShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PurchaseAnAggregateShares"/>
  <xs:element name="ExercisePricePerShare" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="jspr_ExercisePricePerShare"/>
  <xs:element name="AggregateOfferingPrice" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_AggregateOfferingPrice"/>
  <xs:element name="UnderwrittenOfferingRemainedAvailable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_UnderwrittenOfferingRemainedAvailable"/>
  <xs:element name="UnderwritingAgreementSharesOfCommonstock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_UnderwritingAgreementSharesOfCommonstock"/>
  <xs:element name="NetProceedsValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_NetProceedsValue"/>
  <xs:element name="PreFundedWarrantsToPurchase" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PreFundedWarrantsToPurchase"/>
  <xs:element name="CommonWarrantsToPurchaseShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_CommonWarrantsToPurchaseShares"/>
  <xs:element name="NetProceed" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_NetProceed"/>
  <xs:element name="AvailableOfferingAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="jspr_AvailableOfferingAmount"/>
  <xs:element name="StockBasedCompensationDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="jspr_StockBasedCompensationDetailsTable"/>
  <xs:element name="FairMarketValueOfCommonStockPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_FairMarketValueOfCommonStockPercentage"/>
  <xs:element name="PercentageOfFairMarketValueOfShares" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PercentageOfFairMarketValueOfShares"/>
  <xs:element name="IncomeTaxesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="jspr_IncomeTaxesDetailsTable"/>
  <xs:element name="RelatedPartiesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="jspr_RelatedPartiesDetailsTable"/>
  <xs:element name="SubsequentEventsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="jspr_SubsequentEventsDetailsTable"/>
  <xs:element name="AnnualizedSalary" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_AnnualizedSalary"/>
  <xs:element name="PercentageOfPerformanceBonus" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PercentageOfPerformanceBonus"/>
  <xs:element name="AsthmaMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_AsthmaMember"/>
  <xs:element name="BriquilimabPlatformMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_BriquilimabPlatformMember"/>
  <xs:element name="CIndUMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_CIndUMember"/>
  <xs:element name="CMOMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_CMOMember"/>
  <xs:element name="CSUMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_CSUMember"/>
  <xs:element name="CaliforniaInstituteForRegenerativeMedicineMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_CaliforniaInstituteForRegenerativeMedicineMember"/>
  <xs:element name="CommonWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_CommonWarrantsMember"/>
  <xs:element name="DrShizuruMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_DrShizuruMember"/>
  <xs:element name="EmployeeStockPurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EmployeeStockPurchasePlanMember"/>
  <xs:element name="MDSAMLMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_MDSAMLMember"/>
  <xs:element name="OutstandingAndIssuedCommonStockOptionsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_OutstandingAndIssuedCommonStockOptionsMember"/>
  <xs:element name="OutstandingAndIssuedPerformancebasedRestrictedStockUnitsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_OutstandingAndIssuedPerformancebasedRestrictedStockUnitsMember"/>
  <xs:element name="OutstandingAndIssuedRestrictedStockUnitsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_OutstandingAndIssuedRestrictedStockUnitsMember"/>
  <xs:element name="PerformanceBasedStockOptionsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PerformanceBasedStockOptionsMember"/>
  <xs:element name="PerformanceRestrictedStockUnitsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PerformanceRestrictedStockUnitsMember"/>
  <xs:element name="PerformanceShareUnitsPSUsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PerformanceShareUnitsPSUsMember"/>
  <xs:element name="PreFundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PreFundedWarrantsMember"/>
  <xs:element name="ProfessorJudithShizuruMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_ProfessorJudithShizuruMember"/>
  <xs:element name="RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfVotingCommonStockAtAnExercisePriceOf1150Member" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfVotingCommonStockAtAnExercisePriceOf1150Member"/>
  <xs:element name="SCIDMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_SCIDMember"/>
  <xs:element name="September2025OfferingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_September2025OfferingMember"/>
  <xs:element name="SharesAvailableForGrantUnder2022InducementEquityIncentivePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_SharesAvailableForGrantUnder2022InducementEquityIncentivePlanMember"/>
  <xs:element name="SharesAvailableForGrantUnderEmployeeStockPurchasePlansMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_SharesAvailableForGrantUnderEmployeeStockPurchasePlansMember"/>
  <xs:element name="SharesAvailableForGrantUnderEquityIncentivePlansMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_SharesAvailableForGrantUnderEquityIncentivePlansMember"/>
  <xs:element name="SharesIssuableUponExerciseOfCommonStockWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_SharesIssuableUponExerciseOfCommonStockWarrantsMember"/>
  <xs:element name="SharesIssuableUponExerciseOfPreFundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_SharesIssuableUponExerciseOfPreFundedWarrantsMember"/>
  <xs:element name="SharesIssuableUponExerciseOfPublicWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_SharesIssuableUponExerciseOfPublicWarrantsMember"/>
  <xs:element name="ShelfRegistrationStatementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_ShelfRegistrationStatementMember"/>
  <xs:element name="TaxCreditsFederalMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TaxCreditsFederalMember"/>
  <xs:element name="TaxCreditsStateMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TaxCreditsStateMember"/>
  <xs:element name="TwentyTwentyFourStanfordLicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TwentyTwentyFourStanfordLicenseAgreementMember"/>
  <xs:element name="TwentyTwentyOneStanfordLicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TwentyTwentyOneStanfordLicenseAgreementMember"/>
  <xs:element name="TwoThousandTwentyFourPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TwoThousandTwentyFourPlanMember"/>
  <xs:element name="TwoThousandTwentyOneESPPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TwoThousandTwentyOneESPPMember"/>
  <xs:element name="TwoZeroOneNinePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TwoZeroOneNinePlanMember"/>
  <xs:element name="TwoZeroTwoFourESPPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TwoZeroTwoFourESPPMember"/>
  <xs:element name="TwoZeroTwoTwoInducementPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_TwoZeroTwoTwoInducementPlanMember"/>
  <xs:element name="UnderwrittenOfferingsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_UnderwrittenOfferingsMember"/>
  <xs:element name="ValuationOfStockOptionsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_ValuationOfStockOptionsMember"/>
  <xs:element name="VotingCommonStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_VotingCommonStockMember"/>
  <xs:element name="VotingCommonStockParValue00001PerShareMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_VotingCommonStockParValue00001PerShareMember"/>
  <xs:element name="WarrantLiabilityMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_WarrantLiabilityMember"/>
  <xs:element name="CirmGrantDisclosureAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_CirmGrantDisclosureAbstract"/>
  <xs:element name="CirmGrantLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_CirmGrantLineItems"/>
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  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_DocumentAndEntityInformationAbstract"/>
</xs:schema>
