<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com -->
<!-- Created: Wed Jun 10 03:46:13 UTC 2026 -->
<xs:schema elementFormDefault="qualified" xmlns:jspr="http://www.jaspertherapeutics.com/20260610" targetNamespace="http://www.jaspertherapeutics.com/20260610" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:us-types="http://xbrl.us/us-types/2009-01-31" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dtr="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:xbrli="http://www.xbrl.org/2003/instance">
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:type="simple" xlink:href="jspr-20260610_lab.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="jspr-20260610_pre.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="jspr-20260610_def.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef"/>
      <link:roleType roleURI="http://www.jaspertherapeutics.com/role/AdditionalDimensions" id="jspr_r_AdditionalDimensions">
        <link:definition>999000 - Disclosure - Pay vs Performance Disclosure - Additional Dimensions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2024" schemaLocation="https://xbrl.sec.gov/ecd/2024/ecd-2024.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2024" schemaLocation="https://xbrl.sec.gov/dei/2024/dei-2024.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2024" schemaLocation="https://xbrl.sec.gov/ecd/2024/ecd-sub-2024.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei-sub/2024" schemaLocation="https://xbrl.sec.gov/dei/2024/dei-sub-2024.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:element name="AllOtherCompensation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_AllOtherCompensation"/>
  <xs:element name="Bonus" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_Bonus"/>
  <xs:element name="EquityAwards" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwards"/>
  <xs:element name="NonEquityIncentivePlanCompensation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_NonEquityIncentivePlanCompensation"/>
  <xs:element name="NonqualifiedDeferredCompensationEarnings" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_NonqualifiedDeferredCompensationEarnings"/>
  <xs:element name="OptionAwards" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_OptionAwards"/>
  <xs:element name="Pension" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_Pension"/>
  <xs:element name="Salary" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_Salary"/>
  <xs:element name="StockAwards" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="jspr_StockAwards"/>
  <xs:element name="AverageChangeInFairValueFromTheLastDayOfThePriorYearToTheLastDayOfTheYearOfUnvestedEquityAwardsForNonPEONEOsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_AverageChangeInFairValueFromTheLastDayOfThePriorYearToTheLastDayOfTheYearOfUnvestedEquityAwardsForNonPEONEOsMember"/>
  <xs:element name="AverageChangeInFairValueFromTheLastDayOfThePriorYearToTheVestingDateOfUnvestedEquityAwardsThatVestedDuringTheYearForNonPEONEOsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_AverageChangeInFairValueFromTheLastDayOfThePriorYearToTheVestingDateOfUnvestedEquityAwardsThatVestedDuringTheYearForNonPEONEOsMember"/>
  <xs:element name="AverageExclusionOfStockAwardsAndOptionAwardsForNonPEONEOsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_AverageExclusionOfStockAwardsAndOptionAwardsForNonPEONEOsMember"/>
  <xs:element name="AverageInclusionOfEquityValuesForNonPEONEOsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_AverageInclusionOfEquityValuesForNonPEONEOsMember"/>
  <xs:element name="AverageYearEndFairValueOfEquityAwardsGrantedDuringTheYearThatRemainedUnvestedAsOfTheLastDayOfTheYearForNonPEONEOsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_AverageYearEndFairValueOfEquityAwardsGrantedDuringTheYearThatRemainedUnvestedAsOfTheLastDayOfTheYearForNonPEONEOsMember"/>
  <xs:element name="ChangeInFairValueFromTheLastDayOfThePriorYearToTheLastDayOfTheYearOfUnvestedEquityAwardsForPEOMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_ChangeInFairValueFromTheLastDayOfThePriorYearToTheLastDayOfTheYearOfUnvestedEquityAwardsForPEOMember"/>
  <xs:element name="ChangeInFairValueFromTheLastDayOfThePriorYearToTheVestingDateOfUnvestedEquityAwardsThatVestedDuringTheYearForPEOMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_ChangeInFairValueFromTheLastDayOfThePriorYearToTheVestingDateOfUnvestedEquityAwardsThatVestedDuringTheYearForPEOMember"/>
  <xs:element name="ChangeInPensionValueAndEquityAwardValueMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_ChangeInPensionValueAndEquityAwardValueMember"/>
  <xs:element name="EquityAwardsAdjustmentsAdjustmentsForEquityAwardsFailedToMeetPerformanceConditionsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsAdjustmentsAdjustmentsForEquityAwardsFailedToMeetPerformanceConditionsMember"/>
  <xs:element name="EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfCurrentAwardsVestedDuringCurrentYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfCurrentAwardsVestedDuringCurrentYearMember"/>
  <xs:element name="EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearAwardsVestedDuringCurrentYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearAwardsVestedDuringCurrentYearMember"/>
  <xs:element name="EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfVestedAwardsDuringCurrentYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfVestedAwardsDuringCurrentYearMember"/>
  <xs:element name="EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedAwardsGrantedInPriorYearsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedAwardsGrantedInPriorYearsMember"/>
  <xs:element name="EquityAwardsAdjustmentsDividendsOrOtherEarningsPaidOnEquityAwardsNotOtherwiseReflectedInFairValueMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsAdjustmentsDividendsOrOtherEarningsPaidOnEquityAwardsNotOtherwiseReflectedInFairValueMember"/>
  <xs:element name="EquityAwardsAdjustmentsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsAdjustmentsMember"/>
  <xs:element name="EquityAwardsAdjustmentsYearEndFairValueOfAwardsGrantedInCurrentYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsAdjustmentsYearEndFairValueOfAwardsGrantedInCurrentYearMember"/>
  <xs:element name="EquityAwardsValueInCompensationTableForTheApplicableYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_EquityAwardsValueInCompensationTableForTheApplicableYearMember"/>
  <xs:element name="ExclusionOfStockAwardsAndOptionAwardsForPEOMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_ExclusionOfStockAwardsAndOptionAwardsForPEOMember"/>
  <xs:element name="InclusionOfEquityValuesForPEOMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_InclusionOfEquityValuesForPEOMember"/>
  <xs:element name="NetAdjustmentsForEquityAwardsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_NetAdjustmentsForEquityAwardsMember"/>
  <xs:element name="NetAdjustmentsForPensionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_NetAdjustmentsForPensionMember"/>
  <xs:element name="PensionAdjustmentsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PensionAdjustmentsMember"/>
  <xs:element name="PensionAdjustmentsPriorServiceCostMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PensionAdjustmentsPriorServiceCostMember"/>
  <xs:element name="PensionAdjustmentsServiceCostMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PensionAdjustmentsServiceCostMember"/>
  <xs:element name="PensionValueAndEquityAwardsValueInCompensationTableForTheApplicableYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PensionValueAndEquityAwardsValueInCompensationTableForTheApplicableYearMember"/>
  <xs:element name="PensionValueInCompensationTableForTheApplicableYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_PensionValueInCompensationTableForTheApplicableYearMember"/>
<!-- [WMV7][8SCrgmkVAERJLLnLbVU5zuBf6DOUvdbs5tMO3fbwClMrf3R08fLs0k2+lFaqE9+PHUPxAvDgPavscBmhWDFUc/lGkTYXZgH2pzX2TJYSn6GU/31y6JU9A7lzkeGA8uCRf+dUm1IpDN7Fj/K0lf1VTWgthWqGVnz6nX7I3bSYqvDZ+tMfpji7ppoyAH1y50UW2R9fA8gR3etE8N61HuJPeK7/1O452YpOPdzmxhd0I1CTM8ziqK824eKTaCpp+RnMAeUi3B2KM3Xx48B+fGbHN0Y9BYWMPvKhK2kB4QJniAuR5DYkV505zdGEj5F+JKP/Zi+MN+gpnvLO5LrMg/A/qR0LPhkeArUNRwB0jfYHq1aStn5El1EkwsFOQh3OWz1lkzV7hXXblNAKMVy6dl99afS8PEskog==] CSR-->
  <xs:element name="YearEndFairValueOfEquityAwardsGrantedDuringTheYearThatRemainedUnvestedAsOfTheLastDayOfTheYearForPEOMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="jspr_YearEndFairValueOfEquityAwardsGrantedDuringTheYearThatRemainedUnvestedAsOfTheLastDayOfTheYearForPEOMember"/>
</xs:schema>
