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  <xs:element id="jspr_PerformanceBasedStockOptionActivity" name="PerformanceBasedStockOptionActivity" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="jspr_PerformanceRestrictedStockUnitsMember" name="PerformanceRestrictedStockUnitsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_RecognizedCompensationExpensePeriod" name="RecognizedCompensationExpensePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="jspr_StockBasedCompensationDetailsTable" name="StockBasedCompensationDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_TotalEstimatedFairValue" name="TotalEstimatedFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="jspr_TwoThousandTwentyFourPlanMember" name="TwoThousandTwentyFourPlanMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_ScheduleOfRsuActivityAbstract" name="ScheduleOfRsuActivityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_StockBasedCompensationScheduleofRSUActivityDetailsTable" name="StockBasedCompensationScheduleofRSUActivityDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_BriquilimabPlatformMember" name="BriquilimabPlatformMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_CMOMember" name="CMOMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_CSUMember" name="CSUMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_FacilitiesAndOverheadCosts" name="FacilitiesAndOverheadCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="jspr_ScheduleOfSignificantExpenseCategoriesIncludedWithinNetLossPresentedOnTheCompanySCondensedConsolidatedStatementsOfOperationsAndComprehensiveLossAbstract" name="ScheduleOfSignificantExpenseCategoriesIncludedWithinNetLossPresentedOnTheCompanySCondensedConsolidatedStatementsOfOperationsAndComprehensiveLossAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_ScheduleOfDilutedNetLossPerShareAttributableToCommonStockholdersAbstract" name="ScheduleOfDilutedNetLossPerShareAttributableToCommonStockholdersAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="jspr_AsthmaMember" name="AsthmaMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xs:schema>
